Formulasi dan Evaluasi Granul Mukoadhesif Amoksisilin trihidrat dengan Polimer Kitosan

Acute respiratory infection (ARI) is a that causes disruption of normal activities. Amoxicillin the antibiotic first choice generally given to patients with ARI. Compliance in use antibiotics for less than five days will determine success therapy so frequency drug also affects patient compliance taking medication. Granule mucoadhesive amoxicillin trihydrate formula designed addition chitosan polymer expected keep granule stomach longer, as reduce drug. formulated by wet granulation method. The evaluation results showed an increase concentration indicating longer release profile, 6 40% concentration, it could maintain 41% hours testing. Drug kinetics from formulas 1, 3, 4, and 5 followed higuchi kinetics, 2 zero-order first-order kinetics.